Efficacy Study in Mouse Hindlimb Ischemia Model
To surgically induce hindlimb ischemia, one-side common femoral artery and popliteal artery will be ligated and cut. The segment between the two arteries will be isolated and removed resulting in hindlimb ischemia. The blood flow (indicated by the color red in the figure below) is scanned using a Moor LDI laser image. There is no blood flow in the right hindlimb after the hindleg surgery.
Experimental Protocol
Sample Data
Figure 1. (A) D2 Increased Recovery of Blood Flow in Ischemic Hindlimb. *: p<0.01, LI+D2 vs. LI+SA/LI+D1; #: p<0.01, LI+D2 vs. LI+SA; $: p<0.05, LI+D2 vs. LI+SA. (B) D2 Improved Foot Movement in Ischemic Hindlimb. *: p<0.01, LI+D2 vs. LI+SA/LI+D1; #: p<0.01, LI+D2 vs. LI+SA; $: p<0.05, LI+D2 vs. LI+SA. (C) D2 Attenuated Tissue Damage in Ischemic Hindlimb. *: p<0.05, LI+D2 vs. LI+SA; #: p<0.05, LI+D2 vs. LI+SA; $: p<0.05, LI+D2 vs. LI+SA.
