Gene and cell therapy
Transgenic mice and MI mice are common animal models used for gene and cell therapies. Without treatments, the transgenic mice and MI mice will develop heart failure. Viral vectors carrying therapeutic genetic material such as a working gene are delivered into cells through the blood stream or local injection.
CL Laboratory’s models are ideal for testing the efficacy of different gene and cell therapies to show how they reduce the effects of cardiac remodeling and disease progression.
Figure 1. Post-Myocardial Infarction (MI) Remodeling Mouse Model. The left heart in each image shows a SHAM mouse and the right heart shows a mouse that underwent MI surgery.
Echocardiography
Video 1.
Video 2.
The right panel depicts a VIDEO 2.
Video 2. Parasternal short-axis (PSAX) view of a db/db mouse that has left ventricle hypertrophy, a signature cardiac remodeling of diabetic cardiomyopathy.
