Experimental Autoimmune Myocarditis (EAM)
The Experimental Autoimmune Myocarditis (EAM) Model mimics human myocarditis. Myocarditis results from inflammatory cell infiltration and myocardial injury leading to cardiac dilation and dysfunction.
Experimental Protocol
Myocardial Inflammation
Figure 1. (A) H & E staining of cardiac sections. (B) Cardiac inflammation in EAM mice,*: p < 0.01, EAM vs. SHAM.
Mouse Echocardiography
Table 1. Echocardiogram parameters in the SHAM and EAM groups.
Abbreviations: IVSd, Interventricular Septum Thickness at end Diastole; LVEDd, Left-Ventricular End-Diastolic Dimension; LVPTd, Left-Ventricle Posterior Wall Thickness Diastole; IVSs, Interventricular Septum Thickness at end Systole; LVESd, Left-Ventricular End-Systolic Dimension; LVPTs, Left-Ventricle Posterior Wall Thickness Systole; HR, Heart Rate; FS, Fractional Shortening; EF, Ejection Fraction. All parameters are expressed as means ± the SD. The P value was calculated by comparing the final echo of the SHAM and EAM mice.
