Cardiac hypertrophy commonly results from hypertension, a disease can be found in almost half of adults in the United States. The persistent pressure-overload will eventually cause heart failure. TAC is another commonly used animal model for drug development.
TAC model mimics cardiac hypertrophy resulting from hypertension. Cardiac hypertrophy in animal model is usually induced by placing a band at the transverse aortic arch. Dependent on the serverity of a constriction, cardiac function can be compensatory at the early phase. No left ventricular dilation can be seen in echocardiography despite left ventricular hypertrophy.
If left ventricular over-load is persistent, heart failure will develop, presented as dilated left ventricle.
Cardiac hypertrophy can be inhibited in TAC models (upper 10x) by an effective treatment (lower, 10x).
Why Come to Us
Excellence, Efficiency, Ethics
Copyright 2013 CL Laboratory. All rights reserved.