Cardiovascular Research Laboratory
CRO in Animal Models and Preclinical Research
CL Laboratory LLC
Baltimore, MD 21205
1-888-275-2605
Transverse aortic constriction (TAC)
Cardiac hypertrophy commonly results from hypertension, a disease can be found in almost half of adults in the United States. The persistent pressure-overload will eventually cause heart failure. TAC is another commonly used animal model for drug development.
Efficacy Study in TAC (Mouse/Rat)
TAC model mimics cardiac hypertrophy resulting from hypertension. Cardiac hypertrophy in animal model is usually induced by placing a band at the transverse aortic arch. Dependent on the serverity of a constriction, cardiac function can be compensatory at the early phase. No left ventricular dilation can be seen in echocardiography despite left ventricular hypertrophy.
If left ventricular over-load is persistent, heart failure will develop, presented as dilated left ventricle.
Cardiac hypertrophy can be inhibited in TAC models (upper 10x) by an effective treatment (lower, 10x).
