Cardiovascular Research Laboratory

 CRO in Animal Models and Preclinical Research

 

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Baltimore, MD 21205

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    • Myocardial Infarction (MI)
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Transverse aortic constriction (TAC)

Cardiac hypertrophy commonly results from hypertension, a disease can be found in almost half of adults in the United States. The persistent pressure-overload will eventually cause heart failure. TAC is another commonly used animal model for drug development. 

  • Efficacy Study in TAC (Mouse/Rat)

    TAC model mimics cardiac hypertrophy resulting from hypertension. Cardiac hypertrophy in animal model is usually induced by placing a band at the transverse aortic arch. Dependent on the serverity of a constriction, cardiac function can be compensatory at the early phase. No left ventricular dilation can be seen in echocardiography despite left ventricular hypertrophy.

    If left ventricular over-load is persistent, heart failure will develop, presented as dilated left ventricle.

    Cardiac hypertrophy can be inhibited in TAC models (upper 10x) by an effective treatment (lower, 10x).

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