Ventricular Aneurysm and Dilation in MI Mouse

Ventricular Hypertrophy in TAC Mouse 

Systolic Function      

 FS EF IVSd IVSs PWTd PWTs 

Diastolic Function   

 E'/A' E/E' IVRT

Global Function       

 MPI CO

Right Ventricular Pressure-Volume Loop

Right ventricular function (mouse/rat) can be measured by a Millar pressure-volume catheter through its apex or the jugular vein. 

 Left Ventricular Pressure-Volume Loop 

Left ventricular function (mouse/rat) can be measured by a Millar pressure-volume catheter through its apex or the right carotid artery. After MI, left ventricular remodeling causes cardiac dilation and may impair contractile funcion, presented as an increased end-systolic volume and a slope decrease in end-systolic pressure-volume relationship (ESPVR) in infarcted mice (lower) when compared with sham mice (upper). 





However, the slope of ESPVR is increased and end-systolic volume may be decreased in TAC mice (lower) when compared with Sham mice (upper). The slope of end-diastolic pressure-volume relationship (EDPVR) is increased in TAC mice, suggesting a decrease in diastolic function.

LabChart is used to record arterial blood pressure and ventricular ESP, EDP, +dp/dtm, -dp/dtm, SV, EF, ESPVR, and EDPVR.