Leading Cardiovascular CRO in Preclinical Studies
Animal Models
Heart Failure with Preserved EF
- Why come to us?
Expertise: Our team excels in contract cardiovascular research, boasting seasoned professionals with extensive experience and specialized knowledge in preclinical studies. With a deep understanding of cardiovascular diseases and state-of-the-art methodologies, we provide unmatched insights and solutions to tackle complex research inquiries. Clients benefit from our proven track record of delivering high-quality results that drive significant advancements in cardiovascular medicine.
Customized Solutions: Recognizing the uniqueness of each research project, we prioritize customization in our services to meet the distinct needs and objectives of our clients. Whether it’s devising tailored study protocols, refining experimental procedures, or offering adaptable project management solutions, we collaborate closely with clients to develop personalized strategies that optimize efficiency and effectiveness. Our commitment to customization ensures that clients receive bespoke research solutions aligned with their specific goals.
Regulatory Compliance and Quality Assurance: Compliance with regulatory standards and maintaining stringent quality control are fundamental aspects of our approach to contract cardiovascular research in preclinical studies. We possess in-depth knowledge of the complex regulatory landscape governing preclinical research. By strictly adhering to the regulations and implementing robust quality assurance measures, we uphold the integrity and reliability of our research findings, instilling confidence in clients regarding the validity and credibility of our outcomes.
CL Laboratory is an AAALAC
accredited institution.
the Animal Welfare Act and Public Health Service (PHS) Policy on Humane Care
and Use of Laboratory Animals (“PHS Policy”).
Post-MI Remodeling
To develop effective treatment of heart failure, rodent post-MI remodeling is the most commonly used animal model. This animal imitates the pathophysiology of human post- MI ventricular remodeling and heart failure.
Transverse Aortic Constriction (TAC)
Cardiac hypertrophy in animal models is can be induced by placing a band at the transverse aortic arch. Depending on the severity of the constriction, cardiac function can be compensatory at the early phase.
Pulmonary Artery Banding (PAB)
The PAB animal model can be induced by placing a band at the pulmonary trunk. This leads to right ventricular overload and hypertrophy.
What our customers say about us
Ryan M. Fryer, PhD
Boehringer Ingelheim Pharma
Rafe Shellooe, PhD
Plexxicon Inc.
“I really appreciate your thorough and detailed execution of the study from start to finish. I am very happy with your service and will be glad to refer others to you.”